Precision Treatment and Precision Prevention

Precision medicine, technologies, and molecular diagnostics

Introduction: Genetics, cellular and molecular medicines are cutting-edge sciences and technologies that play an important role in improving human health and quality of life. In addition, medical and biological sciences have clearly shown that the onset of diseases differs from person to person due to their different genetic profiles and variations in molecular basis. Therefore, it is feasible ...

Precision prevention of cancer.

Most tumors are incurable once they reach an advanced (e.g., metastatic) stage. Even for those cancers with effective treatment options, prevention has the greatest potential to reduce the burden of cancer in the general population. The 2014 AACR Cancer Progress Report states that a large proportion of cancers could be prevented by modifying factors such as tobacco use (33%), obesity (20%), and...

AccucheckInform II: About Its Accuracy and Precision

Dose distributions of high-precision radiotherapy treatment: A comparison between the CyberKnife and TrueBeam systems

Background: Several high-precision stereotactic radiation therapy modalities are currently used in clinical settings. We aimed to evaluate whether the CyberKnife (CK) or TrueBeam (TB) radiation treatment systems were more appropriate for treating targets of various morphologies according to the physical properties of each device.  Materials and Methods: Spheres (diameter = 5–50 mm), as well as ...

Translating Germline Cancer Risk into Precision Prevention

Study of the biology of tumors caused by germline mutations has led to recent paradigm-changing therapy and is driving precision prevention efforts, including immune oncology and early detection research. Here, we explore recent biologic advances that are redefining the spectrum of cancers linked to various hereditary predisposition syndromes and can be leveraged to improve personalized risk as...